James Jarad Dollar

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

The paper profiles single-cell data from uveal melanoma to show BAP1 loss and PRAME expression drive convergent immunoregulatory changes and immune resistance.

This study identifies BET inhibition as a promising therapeutic strategy for uveal melanoma by demonstrating its efficacy in reducing metastasis and improving survival in a mouse model.

This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.

This study identifies GDF15 as a driver of uveal melanoma liver metastasis by reprogramming hepatic stellate cells to promote angiogenesis and matrix deposition.

PieParty visualizes scRNA-seq data as pie charts where each cell's slices represent gene expression, enabling intuitive and dense visualization of multiple genes and networks.