Author

Nancy Y. A. Sey

University of North Carolina at Chapel HillORCID 0000-0001-8762-7401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:GWAS summary statistics· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Hyejung WoniD· 4 shared Benxia HuiD· 2 shared Bryan C. QuachiD· 2 shared Dana B. HancockiD· 2 shared Eric Otto JohnsoniD· 2 shared Jesse A. MarksiD· 2 shared Schahram AkbarianiD· 2 shared Alex WaldropiD· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Hyejung WonORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 18, 2021

Chromatin architecture in addiction circuitry elucidates biological mechanisms underlying cigarette smoking and alcohol use traits.

Nancy Y. A. Sey, Benxia Hu, Marina Iskhakova…·Hyejung Won

The paper uses Hi-C data to link genetic risk variants for smoking and alcohol use to specific genes and pathways in brain regions involved in addiction.

1 citation

humanHi-C

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GenomicsNature CommunicationsPeer-reviewedNov 3, 2020

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

Bryan C. Quach, Michael A. Bray, Nathan Gaddis…·Dana B. Hancock

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

119 citationstop 1%

humanGWAS summary statistics

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GenomicsbioRxivPreprintSep 25, 2020

A response to Yurko et al: H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

Christiaan de Leeuw, Nancy Y. A. Sey, Daniëlle Posthuma, Hyejung Won

The paper updates H-MAGMA to address statistical issues, showing reduced false positives and consistent results in psychiatric disorder GWAS.

13 citations

humanGWAS summary statistics

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NeuroscienceNature NeurosciencePeer-reviewedMar 9, 2020

Connecting gene regulatory relationships to neurobiological mechanisms of brain disorders

Nancy Y. A. Sey, Benxia Hu, Won Mah…·Hyejung Won

The paper develops H-MAGMA to link genetic variants to gene expression and cell-type specificity in brain disorders, identifying shared and distinct neurobiological mechanisms.

297 citationstop 1%

humanGWAS summary statistics

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