Hongde Liu

The paper identifies potential G-quadruplexes in SARS-CoV-2 and analyzes their binding domain, finding conservation and structural similarities to human transcriptome G-quadruplexes.

DeepSSV detects somatic small variants in paired tumor and normal sequencing data using a convolutional neural network, achieving better performance than existing methods in F1 score.

The paper identifies GMPR1 as a therapeutic target for Alzheimer’s disease, showing lumacaftor reduces β-Amyloid accumulation and Tau phosphorylation in AD model mice.