Pascal Derkinderen

This paper develops a label-free 3D imaging method to detect neurodegenerative changes in intestinal tissue, identifying distinct pathological features in Parkinson's and Alzheimer's disease.

This study examines tau expression and phosphorylation in human enteroendocrine cells, finding that tau is expressed and phosphorylated, with short chain fatty acids modulating its phosphorylation state.

The paper examines tau expression and phosphorylation in Crohn's disease and ulcerative colitis, finding upregulated tau isoforms in Crohn's disease via reduced protein clearance.

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.