Alice Prigent

Lewy pathology accumulates in swollen corticostriatal synapses in α-synucleinopathies

The paper quantifies Lewy pathology burden in the putamen across Lewy body diseases and finds it accumulates in excitatory synapses before synaptic degeneration.

Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation

The paper analyzes longitudinal histopathology data to show that α-synuclein pathology follows rise-and-fall dynamics, revealing a vulnerability axis linked to energy metabolism and monoaminergic neurons.

Helicobacter pylori infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigra

This study shows chronic H. pylori infection causes brain inflammation and dopaminergic neuron loss through inflammation, independent of α-synuclein pathology, and eradication reduces these effects.

A topographical atlas of alpha-Synuclein dosage and cell-type expression in the mouse brain and periphery

This study maps the expression and dosage of alpha-Synuclein across cell types in the mouse brain and periphery, identifying high and low expressing cell types and their potential role in Parkinson's disease.

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease

The paper examines the relationship between glucocerebrosidase activity, lipid levels, and protein pathologies in Parkinson's disease and dementia with Lewy bodies.

Tau accumulates in Crohn's disease gut

The paper examines tau expression and phosphorylation in Crohn's disease and ulcerative colitis, finding upregulated tau isoforms in Crohn's disease via reduced protein clearance.

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.