Christopher W. Moth

AltereGO fuses protein language models and structure representations to predict molecular functions, achieving better performance than individual models and some existing methods.

VUStruct analyzes genetic variants of unknown significance by integrating 3D protein structure data and machine learning to improve clinical and research interpretation of rare genetic disorders.

MutationExplorer provides a webserver to visualize the energetic impacts of protein mutations on 3D structures using Rosetta and supports SNP analysis and sequence uploads.

The paper analyzes missense variants in complement genes to identify spatial associations with AMD risk using structural and functional metrics.

The paper uses personalized structural biology to analyze de novo KCNC2 variants in a DEE patient, revealing distinct functional effects of two nearby variants.

The paper predicts animal species susceptibility to SARS-CoV-2 by analyzing ACE2 receptor sequences and structures to identify key residues that determine infection risk.