Michelle A. Grunin

The Quest for a Universal Parkinson's Transcriptomics Signature is Derailed by Inherent Variability between Patients

This study evaluates the reproducibility and clinical utility of blood mRNA-based gene signatures for Parkinson's disease classification, finding modest performance due to inter-individual variability.

Identifying X-Chromosome Variants Associated with Age-Related Macular Degeneration

This study identifies X-chromosome variants associated with age-related macular degeneration using genome-wide association analysis and pathway enrichment.

Genome-wide association study and genomic risk prediction of age-related macular degeneration in Israel

This study performs a GWAS and evaluates polygenic risk scores for AMD in Israeli populations, finding consistent associations with known loci and demonstrating predictive power of international PRS.

Spatial Distribution of Missense Variants within Complement Proteins Associates with Age Related Macular Degeneration

The paper analyzes missense variants in complement genes to identify spatial associations with AMD risk using structural and functional metrics.

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.