Cancer BiologybioRxivPreprint
Time-Resolved Transcriptomics Reveal Spliceosomal Disruption and Senescence Pathways in Crocin-Treated Hepatocellular Carcinoma Cells
David Roy Nelson, Amphun Chaiboonchoe, Weiqi Fu…·Kourosh Salehi‐Ashtiani
This study uses time-resolved transcriptomics to show crocin disrupts the spliceosome and activates senescence pathways in hepatocellular carcinoma cells, with dose-dependent effects on gene expression and splicing.
DOI 10.1101/2025.08.05.668798