Author

Ala’a Al Hrout

University of ZurichORCID 0000-0001-9130-6774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Richard ChahwaniD· 2 shared Agshin Balayev· 1 shared Amnah Salem Alzahmi· 1 shared Amphun ChaiboonchoeiD· 1 shared Amr AminiD· 1 shared David Roy NelsoniD· 1 shared Julia M. Martínez GómeziD· 1 shared Karīna SiliņaiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Richard ChahwanORCID

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3 papers

Recent·Most cited

Melanoma Response to Immunotherapy is regulated by B Cell-Derived Extracellular Vesicles

Ala’a Al Hrout, Agshin Balayev, Karla Cervantes-Gracia, Konstantinos Gkelis, Stephan Benke-Bruderer, Julia M. Martínez Gómez, Karīna Siliņa, Mitchell Paul Levesque, Richard Chahwan

This study identifies B cell-derived extracellular vesicles and miR-99a-5p as key regulators of melanoma response to immunotherapy.

Science Advances · Oct 8, 2025Peer-reviewedCancer Biology

Time-Resolved Transcriptomics Reveal Spliceosomal Disruption and Senescence Pathways in Crocin-Treated Hepatocellular Carcinoma Cells

David Roy Nelson, Amphun Chaiboonchoe, Weiqi Fu, Amnah Salem Alzahmi, Ala’a Al Hrout, Amr Amin, Kourosh Salehi‐Ashtiani

This study uses time-resolved transcriptomics to show crocin disrupts the spliceosome and activates senescence pathways in hepatocellular carcinoma cells, with dose-dependent effects on gene expression and splicing.

bioRxiv · Aug 5, 2025 · PreprintCancer Biology

Intercellular epigenomic signaling during B cell maturation.

Kevin Ho Wai Yim, Ala’a Al Hrout, Richard Chahwan

The paper investigates the role of B cell extracellular vesicles in maturation, identifying miR-5099 and long non-coding RNAs as key regulators of antibody diversification.

Journal of Extracellular Vesicles · Jan 1, 2025Peer-reviewedImmunology