Time-Resolved Transcriptomics Reveal Spliceosomal Disruption and Senescence Pathways in Crocin-Treated Hepatocellular Carcinoma Cells
David Roy Nelson, Amphun Chaiboonchoe, Weiqi Fu, Amnah Salem Alzahmi, Ala’a Al Hrout, Amr Amin, Kourosh Salehi‐Ashtiani
This study uses time-resolved transcriptomics to show crocin disrupts the spliceosome and activates senescence pathways in hepatocellular carcinoma cells, with dose-dependent effects on gene expression and splicing.
bioRxiv · Aug 5, 2025 · PreprintCancer Biology