Author

Thommas Mutemi Musyoka

Kenyatta UniversityORCID 0000-0001-8906-9482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:protein structure· 2 Approach:deep learning· 1 Organism:plant (other)· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Özlem Taştan BishopiD· 2 shared Collins Misita Morang’aiD· 1 shared Elcanah Mauta EvansiD· 1 shared Esther Mary Munyoki Toili· 1 shared Francisca Mutindi· 1 shared Gracia D Mave· 1 shared Jaindra Nath TripathiiD· 1 shared Joyce Njoki NjugunaiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioinformatics

Özlem Taştan BishopORCID

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Author profile →

4 papers

Recent·Most cited

Expanding the repertoire of suicidal germination stimulants for control of parasitic weeds

Gracia D Mave, Thommas Mutemi Musyoka, Sylvia Mutinda, Francisca Mutindi, Willy Kibet, Esther Mary Munyoki Toili, Samuel Muiruri, Justus Onguso, Jaindra Nath Tripathi, Leena Tripathi, Steven Maina Runo

The paper identifies a new strigolactone analog using AlphaFold2-based in silico screening, offering a cost-effective method for suicidal germination of Striga weeds.

bioRxiv · Apr 16, 2026 · PreprintPlant Biology

Discovery of Novel Trypanothione Reductase Inhibitors through Pharmacophore Modeling, virtual Screening and Molecular Dynamics Simulations. New insights for Human African Trypanosomiasis

Elcanah Mauta Evans, Oluwaseun Oluwatosin Taofeek, Theresa Manful Gwira, Collins Misita Morang’a, Thommas Mutemi Musyoka, Steven Ger Nyanjom

The paper identifies two novel inhibitors of Trypanothione Reductase through pharmacophore modeling, virtual screening, and molecular dynamics simulations, showing better efficacy than Melarsoprol.

bioRxiv · Apr 18, 2025 · PreprintBioinformatics

Force field parameters for Fe2+4S2-4 clusters of dihydropyrimidine dehydrogenase, the 5-fluorouracil cancer drug deactivation protein: a step towards in silico pharmacogenomics studies

Maureen Bilinga Tendwa, Lorna J. Chebon, Kevin Alan Lobb, Thommas Mutemi Musyoka, Özlem Taştan Bishop

The paper derives AMBER force field parameters for Fe2+4S2-4 clusters in DPD enzyme to improve in silico studies of 5-FU drug metabolism and toxicity.

Molecules · May 14, 2021Peer-reviewedBioinformatics

Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide-based inhibitor design

Thommas Mutemi Musyoka, Joyce Njoki Njuguna, Özlem Taştan Bishop

The paper identifies sequence and structural differences between falcipains and human cathepsins to design selective peptide inhibitors for malaria treatment.

Malaria Journal · May 3, 2019Peer-reviewedBioinformatics