Collins Misita Morang’a

The Reasoning Paradox in Scientific Sandboxes: Why Extended Reasoning Fails in Autonomous Bioinformatics and How to Fix It.

This paper identifies two failure modes in extended reasoning models within bioinformatics tasks and introduces DTDR to improve accuracy and reduce errors.

Tensorizing Pairwise Structural Analysis: GPU-Accelerated RMSD and FCC Clustering in HADDOCK3 Without Structural Regression.

The paper accelerates structural analysis in HADDOCK3 by reformulating RMSD and FCC clustering as GPU-based linear algebra operations, achieving significant speedups without compromising accuracy.

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

Discovery of Novel Trypanothione Reductase Inhibitors through Pharmacophore Modeling, virtual Screening and Molecular Dynamics Simulations. New insights for Human African Trypanosomiasis

The paper identifies two novel inhibitors of Trypanothione Reductase through pharmacophore modeling, virtual screening, and molecular dynamics simulations, showing better efficacy than Melarsoprol.

Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum

This study implements a Nanopore sequencing workflow for P. falciparum genomic surveillance in Ghana, identifying drug resistance patterns and vaccine antigen variations.

Molecular epidemiology of Infectious Spleen and Kidney Necrosis Virus (ISKNV) in Ghanaian cultured tilapia

This study investigates the molecular epidemiology of ISKNV in Ghanaian tilapia, finding high prevalence and genotype I across Lake Volta farms.

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

This study uses genomic data from 8746 SARS-CoV-2 genomes across 33 African countries to show that most epidemics were initiated by European importations and later driven by local transmission and mobility, leading to the spread of variants of concern.