Aritra Gupta

The paper identifies a JMJD6-YBX1 transcriptional axis that reprograms chromatin and sustains tumor proliferation in ER+ breast cancer cells through enhancer redistribution and altered signaling pathways.

The paper shows JMJD6 and YBX1 physically interact and regulate HOTAIR promoter activity through a positive feedback loop, contributing to tumor progression.

This study identifies five circulating extracellular vesicle RNAs that can diagnose breast cancer independently of subtypes and detect metastatic states.