Kartiki Vasant Desai

The paper identifies a JMJD6-YBX1 transcriptional axis that reprograms chromatin and sustains tumor proliferation in ER+ breast cancer cells through enhancer redistribution and altered signaling pathways.

The paper shows JMJD6 and YBX1 physically interact and regulate HOTAIR promoter activity through a positive feedback loop, contributing to tumor progression.

This study identifies five circulating extracellular vesicle RNAs that can diagnose breast cancer independently of subtypes and detect metastatic states.

The paper identifies miR-497/195 suppression as a mechanism of endocrine therapy resistance in breast cancer, linking it to elevated FLT4 and MIR503HG expression through RNA-seq and ceRNA network analysis.