Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons
Hu Wang, Rong Chen, Liming Xiao, Manoj Kumar, Jesús A. Acevedo-Cintrón, Joanna S. Siuda, Dariusz Koziorowski, Zbigniew K. Wszołek, Valina Lynn Dawson, Ted M. Dawson
This study shows that defects in mitochondrial biogenesis, not mitophagy, are the primary cause of mitochondrial alterations in PINK1-deficient human dopamine neurons.
bioRxiv · Jun 23, 2023 · PreprintNeuroscience