Elise Lim

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

The paper estimates heritability for height and BMI using whole-genome sequence data and finds that rare variants contribute significantly to the missing heritability.

The paper identifies novel genetic loci associated with blood pressure that interact with sleep duration across multiple ancestries.

This study identifies DNA methylation sites associated with central adiposity traits in adults and adolescents using methylome-wide association analyses across multiple cohorts.

The paper introduces MAGEE, a method for efficient gene-environment interaction testing in large biobank-scale sequencing studies, reducing computational burden and enabling analysis of hundreds of thousands of individuals.

This paper introduces a unified method for detecting gene-environment interactions involving rare variants using a generalized linear mixed effect model, showing it maintains correct type I error and high power in simulations and replicates a known association.

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.