Author

Nisha D Kamath

Case Western Reserve UniversityORCID 0000-0001-8969-0631Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Kenneth A. MatreyekiD· 2 shared Anna M. BrucheziD· 1 shared John C SnelliD· 1 shared Nidhi ShuklaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersGenetics

Kenneth A. MatreyekORCID

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2 papers

Recent·Most cited

GeneticsGeneticsPeer-reviewedJul 30, 2025

Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function

Nisha D Kamath, Kenneth A. Matreyek

The paper functionally characterizes 706 STIM1 EF-hand variants using overexpression fitness costs in human cells, revealing structural and functional constraints and implications for disease.

5 citations

humanexperimental assay

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GeneticsbioRxivPreprintApr 28, 2025

Kozak sequence libraries for characterizing transgenes across expression levels

Nidhi Shukla, Nisha D Kamath, John C Snell…·Kenneth A. Matreyek

The paper uses Kozak sequence libraries to modulate protein abundance and function, showing their impact on viral infection rates and identifying disease-associated variants.

5 citations

humanproteomics

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