Author

John C Snell

Case Western Reserve UniversityORCID 0000-0003-2683-6108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Organism:non-human primate· 1 Research Focus:protein design· 1

Frequent Co-Authors

Kenneth A. MatreyekiD· 3 shared Anna M. BrucheziD· 2 shared Nidhi ShuklaiD· 2 shared Nisha D KamathiD· 1 shared Olivia DelSignore· 1 shared Sarah M. RoelleiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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3 shared papersGenetics

Kenneth A. MatreyekORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintJul 16, 2026

High Throughput Characterization of Eukaryotic 2A-Like Peptides Identifies Novel Leucine-Associated Reduction in Protein Abundance

John C Snell, Kenneth A. Matreyek

The paper identifies novel leucine-associated reduction in protein abundance linked to 2A-like peptides from eukaryotes using a high-throughput fluorescent reporter tool.

DOI 10.64898/2026.06.17.732966

proteomicsexperimental assay

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GeneticsbioRxivPreprintApr 28, 2025

Kozak sequence libraries for characterizing transgenes across expression levels

Nidhi Shukla, Nisha D Kamath, John C Snell…·Kenneth A. Matreyek

The paper uses Kozak sequence libraries to modulate protein abundance and function, showing their impact on viral infection rates and identifying disease-associated variants.

5 citations

humanproteomics

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GeneticsPLoS PathogensPeer-reviewedMay 20, 2024

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage

Nidhi Shukla, Sarah M. Roelle, John C. Snell…·Kenneth A. Matreyek

The paper uses a pseudotyped virus infection assay to assess how SARS-CoV-2 variants interact with ACE2 receptor variants across species, revealing structural and compatibility shifts.

6 citations

humannon-human primate

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