Shin‐ichi Sakakibara

Induction of NASH in the Nwd1-/- mouse liver via SERCA2-dependent endoplasmic reticulum stress

This study shows that Nwd1 knockout mice develop NASH-like liver pathology due to SERCA2 dysfunction and ER stress.

Spatiotemporal regulation of de novo and salvage purine synthesis during brain development

This study investigates the spatiotemporal regulation of de novo and salvage purine synthesis during brain development and finds that their utilization shifts from de novo in embryonic stages to salvage in postnatal-adult stages, with implications for mTOR signaling and brain morphology.

Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development

This study identifies Inka2 as a Pak4 inhibitor that regulates actin dynamics in neuronal development by promoting depolymerization and inhibiting protrusion formation.

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

This study shows that Senp5 isoforms regulate Drp1 SUMOylation, affecting ER tubulation and mitochondrial dynamics during brain development.

Nwd1 regulates neuronal differentiation and migration through purinosome formation in the developing cerebral cortex

This study shows that Nwd1 regulates purinosome formation in neural stem/progenitor cells, affecting neuronal differentiation and migration in the developing cerebral cortex.