Izuho Hatada

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

The paper identifies a stress-induced pain circuit involving locus coeruleus noradrenergic neurons and spinal astrocytes in mice, showing their role in mechanical pain hypersensitivity.

This study identifies LRBA as a scaffold promoting MAPK activation, leading to drug-induced liver injury and MASLD by enhancing inflammatory signaling.

The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.

This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

This study shows that Nwd1 knockout mice develop NASH-like liver pathology due to SERCA2 dysfunction and ER stress.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.