Sishir Subedi

This study identifies Cnpy1 as an ER chaperone essential for V2R GPCR function and Go neuron survival in mice.

This paper introduces a scalable topic modeling method for single-cell RNA-seq data that reduces computational demands while maintaining accuracy and enabling integration with bulk data.

SPRUCE identifies common cell-cell communication patterns in breast cancer single-cell RNA-seq data, revealing seven interaction signatures and gene networks that explain tumour heterogeneity beyond marker gene expression.

The paper compares ARTIC V3 and V4 primer sets for SARS-CoV-2 sequencing, finding improved performance and underrepresentation of G142D substitution in early Delta genomes due to V3 primer limitations.

The paper sequences 320 SARS-CoV-2 genomes from Houston to study early pandemic spread, finding diverse origins and no evidence of more virulent strains.