Culture filtrate selectively promotes Mycobacterium tuberculosis growth from extremely low density inocula: implications for quantifying differentially culturable phenotypes
Ryan Dinkele, Ditshego Benjamin Ralefeta, Atica Moosa, Digby Francis Warner, Sophia J. Gessner
This study shows that culture filtrate selectively enhances Mycobacterium tuberculosis growth from low inoculum densities, but its effect diminishes at higher densities, suggesting limitations in current culturing methods.
bioRxiv · Oct 15, 2025 · PreprintMicrobiology