Brian Yuan Chen

DeepVASP-S predicts amino acid contributions to binding specificity using CNNs and explains steric mechanisms in protein-ligand interactions.

MechPPI predicts protein-protein binding affinity changes due to mutations by using mechanism-based features, showing accuracy in single mutation analysis.

The paper introduces BANSA, a method to align bond networks from protein-protein interactions using bond formation as anchors, validated through heatmap analysis and comparison with existing literature.

DeepVASP-E identifies electrostatic mechanisms influencing binding specificity by classifying ligand binding sites and highlighting salient electrostatic regions.