Author

Wenxue Li

Yale UniversityORCID 0000-0002-0346-5300Unclaimed ORCID profile · follow to get notified of new preprints

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Wenxue Li2 papers · Yale University

Biology Disciplines

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Systems Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Yansheng LiuiD· 3 shared Aaron Timothy GriffiniD· 1 shared Andrea CalifanoiD· 1 shared Barbora ŠalovskáiD· 1 shared Barry H. HonigiD· 1 shared Cassandra Santaella BishopiD· 1 shared Charles KaraniD· 1 shared Chongde WuiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersSystems Biology

Yansheng LiuORCID

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3 papers

Recent·Most cited

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

Xiangyu Ge, Jaffarguriqbal Singh, Wenxue Li, Cassandra Santaella Bishop, Christian Felipe Ruiz, Moitrayee Bhattacharyya, Yansheng Liu, Mandar Deepak Muzumdar

This study shows PI3K promotes resistance to KRAS inhibition in PDAC by activating wild-type RAS signaling through GAB1 recruitment and MAPK activation.

bioRxiv · Jun 20, 2025 · PreprintCancer Biology

Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis

George Rosenberger, Wenxue Li, Mikko M. Turunen, Jing He, Prem S. Subramaniam, Sergey Pampou, Aaron Timothy Griffin, Charles Karan, Patrick Kerwin, Diana Murray, Barry H. Honig, Yansheng Liu, Andrea Califano

The paper uses phosphoproteomic time-series data and the VESPA algorithm to analyze drug resistance mechanisms in colon cancer cells, revealing adaptive signaling rewiring confirmed by CRISPRko assays.

bioRxiv · Feb 15, 2023 · PreprintSystems Biology

Rapid Proteomic Screen of CRISPR Experiment Outcome by Data Independent Acquisition Mass Spectrometry: A Case Study for HMGN1

Martin Mehnert, Wenxue Li, Chongde Wu, Barbora Šalovská, Yansheng Liu

This study uses DIA-MS to rapidly assess proteomic changes after CRISPR-mediated HMGN1 knockout in cancer cells, identifying 147 significantly altered proteins and their functional impacts.

bioRxiv · Dec 9, 2018 · PreprintSystems Biology