RNA polymerase inhibitors reveal active-site motions essential for the nucleotide-addition cycle
Yukti Dhingra, Robert C. Landick, Elizabeth A. Campbell, Seth Andrew Darst
This study shows that RNA polymerase inhibitors prevent RH-FL closure, destabilizing the trigger loop and inhibiting the nucleotide-addition cycle.
Proceedings of the National Academy of Sciences · Jun 30, 2026Peer-reviewedBiochemistry