Comprehensive quantification of the modified proteome reveals oxidative heart damage in mitochondrial heteroplasmy
Navratan Bagwan, Elena Bonzón‐Kulichenko, Enrique Calvo, Ana Victoria Lechuga‐Vieco, Spiros Michalakopoulos, Marco Trevisán-Herraz, Iakes Ezkurdia, José Manuel Rodrı́guez, Ricardo Magni, Ana Latorre-Pellicer, José Antonio Enrı́quez, Jesús Vázquez
The paper develops algorithms to comprehensively identify and quantify protein modifications, revealing oxidative damage in heart mitochondria due to mtDNA heteroplasmy.
Cell Reports · Jun 1, 2018Peer-reviewedBioinformatics