Jesús Vázquez

TurbOmics is a web-based platform that enables multi-omics integration of metabolomics, proteomics, and transcriptomics data, addressing limitations in metabolomics annotation and accessibility.

This study identifies lamin A/C as a regulator of intestinal inflammation and tumorigenesis by modulating immune and stromal cell functions in mouse models and human IBD biopsies.

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

This study identifies MT4-MMP as a regulator of NRP1 shedding, which modulates VEGFA signaling during embryonic brain angiogenesis and wound repair.

EpiFlow quantifies 16 epigenetic markers per cell using spectral flow cytometry, showing broad applicability across species and biological processes.

This study shows that smooth-muscle calcineurin, independent of its phosphatase activity, drives a gene expression program that causes hypertension.

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

This study shows Arabidopsis ING2 regulates flowering by modulating histone H4 acetylation at FT and SOC1 loci through its association with the NuA4 complex.

The paper introduces a workflow for analyzing post-translational modifications using proteomics data, revealing new oxidative modifications in animal models.

The paper introduces PACREDOX, a redox proteomics method that improves efficiency and compatibility with DIA, quantifying thousands of proteins and modified peptides in myocardial tissue.

The paper analyzes the PeptideAtlas database to identify unannotated coding genes and aberrant translation, finding 34 novel ORFs with peptide evidence.

This study uses CRISPR/Cas9 screening to identify novel regulators of mitochondrial oxidative metabolism, revealing key genes involved in complex I assembly and BCAA catabolism.

The paper shows that in-gel protein digestion with acidic methanol selectively methylates glutamic acid residues, not other methylable residues like aspartic acid.

iSanXoT provides a standalone tool for integrative analysis of quantitative proteomics data, offering features like error distribution modeling and workflow customization.

ReCom improves peptide identification by using a semi-supervised approach with a reference database, increasing performance by 68% over Comet-PTM.

The paper shows that APPRIS principal isoforms and MANE Select transcripts align well with main protein isoforms and are critical for clinical variant interpretation.

This study investigates the role of SCAF1 in mitochondrial respiratory supercomplexes in mice, showing its structural role in respirasome formation and its impact on respiration and ROS production.

The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.

This study investigates the effects of HIF1α deletion in cardiac progenitors during heart development, finding that HIF1 is dispensable for cardiac growth and reveals metabolic reprogramming toward amino acid utilization.

The paper develops algorithms to comprehensively identify and quantify protein modifications, revealing oxidative damage in heart mitochondria due to mtDNA heteroplasmy.

SQANTI characterizes long-read transcript sequences to assess quality and improve quantification of full-length transcriptomes.

QuiXoT provides a robust statistical framework for quantifying and analyzing high-throughput proteomics data using stable isotope labeling, with tools for visualization and model inspection.