Elena Bonzón‐Kulichenko

The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.

This study investigates the effects of HIF1α deletion in cardiac progenitors during heart development, finding that HIF1 is dispensable for cardiac growth and reveals metabolic reprogramming toward amino acid utilization.

The paper develops algorithms to comprehensively identify and quantify protein modifications, revealing oxidative damage in heart mitochondria due to mtDNA heteroplasmy.

QuiXoT provides a robust statistical framework for quantifying and analyzing high-throughput proteomics data using stable isotope labeling, with tools for visualization and model inspection.