Ana Victoria Lechuga‐Vieco

Mitochondrial genetics defines anti-tumour immunity through mitochondrial ROS and PD-1 signalling

This study shows mitochondrial haplogroups affect tumour growth and anti-tumour immunity through mitochondrial ROS and PD-1 signalling in mouse models.

Butyrate extends health and lifespan in mice with mitochondrial deficiency

This study shows that butyrate supplementation improves health and extends lifespan in mice with mitochondrial dysfunction by restoring intestinal barrier function and epigenetic marks.

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic.

Comprehensive quantification of the modified proteome reveals oxidative heart damage in mitochondrial heteroplasmy

The paper develops algorithms to comprehensively identify and quantify protein modifications, revealing oxidative damage in heart mitochondria due to mtDNA heteroplasmy.