Christophe de La Roche Saint-André

Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae

The paper shows that aneuploidy in yeast can enhance cell proliferation by extending the G1 phase, compensating for defects in DNA replication licensing.

Set1-dependent H3K4 methylation becomes critical for DNA replication fork progression in response to changes in S phase dynamics in Saccharomyces cerevisiae

The paper shows that Set1-dependent H3K4 methylation is critical for DNA replication fork progression when replication forks accelerate due to reduced origin firing in yeast.