Vincent Géli

TERT drives liver tumorigenesis beyond telomere elongation

This study shows TERT promotes liver tumors independently of telomere elongation, revealing molecular and metabolic features relevant to immunotherapy response.

Non-canonical TERT function mitigates adipose tissue inflammation in obesity by modulating stem cell-macrophage communication and macrophage states

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections

The paper identifies new interactors of the SET1C complex through yeast two-hybrid screens, revealing its roles in chromatin regulation, RNA biogenesis, and nuclear transport.

TERT prevents obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation

This study shows that TERT reduces obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation, and remodeling macrophages in adipose tissue.

Xrs2 C-terminus mediates Tel1-dependent meiotic double-strand break interference

This paper investigates how Tel1 interacts with Xrs2 to regulate meiotic DNA break interference and the DNA damage checkpoint in yeast.

Induction of telomerase in p21-positive cells counteracts capillaries rarefaction in aging mice lung

The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.

UFMylation of MRE11 is essential for telomere length and hematopoietic stem cell survival

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.

Set1-dependent H3K4 methylation becomes critical for DNA replication fork progression in response to changes in S phase dynamics in Saccharomyces cerevisiae

The paper shows that Set1-dependent H3K4 methylation is critical for DNA replication fork progression when replication forks accelerate due to reduced origin firing in yeast.

Telomerase Prevents Emphysema in Old Mice by Sustaining Subpopulations of Endothelial and AT2 Cells

This study shows that telomerase expression in old mice prevents emphysema by maintaining endothelial and AT2 cell populations through increased proliferation.