Fuyuki Kametani

The paper reports that tau filaments in vacuolar tauopathy with VCP mutation D395G have the CTE fold, similar to environmentally induced diseases.

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

This study shows that macrophages in the reticuloendothelial system remove amyloid fibrils and prevent their spread in a mouse model of apolipoprotein A-II amyloidosis.

This study shows curcumin increases AApoAII amyloid deposition and liver weight in mice by activating PPARα, affecting lipid metabolism and Apoa2 expression.

This study determines the structure of α-synuclein filaments in multiple system atrophy using cryo-EM, revealing distinct filament types and conformers that differ from in vitro assemblies.