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Structure-based Classification of Tauopathies
Yang Shi, Wenjuan Zhang, Yang Yang…·Sjors H. W. Scheres
Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.