Molecular BiologybioRxivPreprint
A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways
Jennifer L. Mamrosh, David J. Sherman, Joseph R. Cohen…·Raymond J. Deshaies
The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.
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