Author

James A. Johnston

Amgen (United States)ORCID 0000-0002-0708-3684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Annie MoradianiD· 1 shared Brett LomenickiD· 1 shared Bryan Vander Lugt· 1 shared David J. ShermaniD· 1 shared James Russell Lipford· 1 shared Jennifer L. MamroshiD· 1 shared Jing LiiD· 1 shared Joseph R. Cohen· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Annie MoradianORCID

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1 paper

Recent·Most cited

A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways

Jennifer L. Mamrosh, David J. Sherman, Joseph R. Cohen, James A. Johnston, Marisa K. Joubert, Jing Li, James Russell Lipford, Brett Lomenick, Annie Moradian, Siddharth Prabhu, Michael J. Sweredoski, Bryan Vander Lugt, Rati Verma, Raymond J. Deshaies

The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.

bioRxiv · Oct 7, 2021 · PreprintMolecular Biology