Author

David J. Sherman

Amgen (United States)ORCID 0000-0002-2120-0971Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Raymond J. DeshaiesiD· 2 shared Annie MoradianiD· 1 shared Brett LomenickiD· 1 shared Bryan Vander Lugt· 1 shared Danielle PruittiD· 1 shared Edward L. LaGoryiD· 1 shared Ingrid C. RulifsoniD· 1 shared James A. JohnstoniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Raymond J. DeshaiesORCID

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2 papers

Recent·Most cited

Cell BiologyCell ReportsPeer-reviewedOct 1, 2025

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory…·Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

9 citationstop 3%

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Molecular BiologybioRxivPreprintOct 7, 2021

A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways

Jennifer L. Mamrosh, David J. Sherman, Joseph R. Cohen…·Raymond J. Deshaies

The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.

1 citation

humanproteomics

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