ImmunologyVirulencePeer-reviewed
PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation
Yulin Xu, Chenglin Chi, Qihang Xin…·Jianzhong Zhu
This study identifies PRRSV's Nsp5 protein as a mechanism to inhibit the cGAS-STING-IFN antiviral pathway by blocking STING translocation and activation, thereby promoting viral replication.