Chenglin Chi

This study isolates and analyzes two G4 Eurasian avian-like H1N1 swine influenza viruses, showing they have enhanced pathogenicity in mice and pigs due to molecular features like HA receptor affinity and polymerase activity.

This study identifies ASFV p30's role in suppressing antiviral type I IFN induction by interacting with TRIM21 and MAVS, disrupting TRIM21-mediated K27 polyubiquitination of MAVS.

This study identifies K61-mediated K48 ubiquitination and proteasome degradation of porcine STING as a species-specific mechanism regulating antiviral signaling.

This study identifies PRRSV's Nsp5 protein as a mechanism to inhibit the cGAS-STING-IFN antiviral pathway by blocking STING translocation and activation, thereby promoting viral replication.