The use of two-sample methods for Mendelian randomization analyses on single large datasets
Cosetta Minelli, Fabiola Del Greco M, Diana A. van der Plaat, Jack Bowden, Nuala A. Sheehan, John Russell Thompson
This paper evaluates the performance of two-sample Mendelian randomization methods in one-sample MR analyses, finding that most methods perform well except MR-Egger, which shows bias due to confounding.
International Journal of Epidemiology · Apr 6, 2021Peer-reviewedGenetics