Thibaud Boutin

This study conducts a genome-wide association study (GWAS) of ME/CFS, identifying eight genetic loci associated with the disease, suggesting involvement of immune and neurological processes.

SNHap-RHM jointly maps common and rare genetic variation affecting complex traits by combining SNP and haplotype-based genomic relationship matrices, identifying significant genomic regions for height and MDD.

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

This study identifies DNA methylation loci associated with age-by-sex interactions in a cohort of 2,586 individuals, finding most significant loci are X-linked and linked to disease-related genes.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

This study identifies 11 genome-wide significant loci for retinal detachment by combining small clinical and large population-based datasets, with six loci replicated in an independent dataset.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.