This study compares IFNγ-induced iNOS activity in human and murine tuberculosis models, finding minimal iNOS expression in human myeloid cells and identifying epithelial cells as primary iNOS sources.

American Journal of Respiratory Cell and Molecular Biology · Aug 12, 2026Peer-reviewedImmunology

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

Nick R. G. Shrine, Abril G. Izquierdo, Jing Chen, Richard J. Packer, Robert J. Hall, Anna L. Guyatt, Chiara Batini, Rebecca J. Thompson, Chandan K Pavuluri, Vidhi Malik, Brian D. Hobbs, Matthew R. Moll, Wonji Kim, Ruth Tal‐Singer, Per Sigvald Bakke, , Data Management and Computing Infrastructure group

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

Nature Genetics · Mar 1, 2023Peer-reviewedGenetic & Genomic Medicine

SNPs associated with HHIP expression have differential effects on lung function in males and females

Katherine A. Fawcett, Ma’en Obeidat, Carl Melbourne, Nick R. G. Shrine, Anna L. Guyatt, Catherine John, Jian’an Luan, Anne Richmond, Marta Riise Moksnes, Raquel Granell, Stefan Weiß, Medea Imboden, Sebastian May-Wilson, Pirro G. Hysi, Thibaud Boutin, , Louise V. Wain

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

Wellcome Open Research · Jun 1, 2020Peer-reviewedGenetics

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick R. G. Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C. Latourelle, Xingnan Li, Jarrett D. Morrow, Ma’en Obeidat, , Nicholas J. Wareham

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

Nature Genetics · Feb 25, 2019Peer-reviewedGenetics

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

Nick R. G. Shrine, Anna L. Guyatt, Abdullah Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung S Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F. Reeve, Ma’en Obeidat, Jing Hua Zhao, , Andrew P. Morris

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma’en Obeidat, Michael A. Province, Wei Dong Gao, Beenish Qaiser, David John Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, , Sven Gläser

Wellcome Open Research · Jan 12, 2018Peer-reviewedGenetics