Jan de Boer

Micellangelo generates high-resolution fluorescence images of cells on micro-topographical surfaces, enabling in silico exploration of cell-material interactions.

The paper identifies a Golgi regulon and shows CREB3L1 drives its transcriptional activation during de novo Golgi biogenesis.

The paper optimizes biomaterial surface topographies using evolutionary algorithms inspired by natural selection to enhance osteogenic marker expression.

This study investigates how cell shape affects the phenotypic response of human mesenchymal stem cells and identifies molecular mechanisms linking shape to function.