Yumiko Saga

This study uses AID-mediated NANOS2 knockdown to show that sustained NANOS2 expression is essential for establishing functional spermatogonial stem cells during embryonic development.

This study shows DDX6 regulates early mouse embryogenesis by repressing negative BMP regulators via miRNA-mediated gene silencing, affecting cell lineage specification and germ layer development.

The paper identifies Nhlh1 and Nhlh2 as transcription factors that globally regulate commissural axon laterality through Robo3 activation in mammals.

The paper identifies a novel genetic compensation mechanism where the Mesp2 enhancer interacts with the Mesp1 promoter to upregulate Mesp1 in response to Mesp2 loss.

This paper identifies a medaka mutant with congenital intestinal atresia, linking Mypt1 dysfunction to actomyosin dysregulation and epithelial disorganisation.

The paper uses scRNA-seq to show NANOS2 induces mitotic arrest in male germ cells by repressing mTORC1 activators like Rheb.

This study shows that Sox17 expression in cardiac progenitor cells biases their fate toward the endocardium and regulates myocardium development through NOTCH signaling in mice.