Ryuki Shimada

The paper shows MEIOSIN has a STRA8-independent activity that drives meiotic entry in vertebrates, with different effects in zebrafish and mice.

This study identifies an Nkx2.3-Nr5a1 gene regulatory axis critical for spleen-specific vascular architecture and marginal zone formation in mice.

This study identifies MAP7 as a key regulator of microtubule remodeling in Sertoli cells, essential for apical domain formation and timely meiotic progression in mouse testes.

This study identifies HSF5 as a male germ cell-specific factor critical for meiotic prophase progression beyond pachytene under non-stress conditions.

This study identifies ATF7IP2 as a critical regulator of H3K9 methylation and meiotic gene regulation in male germline, showing its role in heterochromatin organization and meiotic sex chromosome inactivation.

The paper uses scRNA-seq to show NANOS2 induces mitotic arrest in male germ cells by repressing mTORC1 activators like Rheb.

This study identifies a ZFP541-KCTD19 repressor complex that promotes meiotic prophase exit in spermatogenesis by suppressing transcriptional regulators and chromatin modifiers.