Dara S. Manoach

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

The paper shows that hippocampal ripples during rest breaks predict motor learning in humans, suggesting a role for ripples in procedural memory.

Auditory stimulation during sleep increases slow oscillations and SO-spindle complexes, which correlate with improved memory consolidation in children with epilepsy and controls.

This study uses EEG-PET-MRI to show how hemodynamic and metabolic dynamics change during wakefulness and NREM sleep, revealing coupled temporal patterns and distinct network activity.

The paper examines sleep spindle activity and memory consolidation in early psychosis patients and their relatives, finding spindle deficits and memory issues in patients but not relatives.

This study replicates group-level sleep EEG differences in schizophrenia and shows increased patient-to-patient variability in NREM metrics, with medication and age-related effects contributing to this heterogeneity.

This study finds that reduced sleep spindles in children with active Rolandic epilepsy predict impaired sleep-dependent memory consolidation.

The paper shows that epileptic spikes during sleep block sleep spindle production in thalamic recordings of patients with epileptic encephalopathy.

This study identifies biases in group-level EEG microstate analysis and proposes a paired analysis approach to reduce errors from subgroup topography differences.

This study identifies NREM sleep and wake EEG biomarkers associated with schizophrenia symptom severity and disease status.

The paper creates a normative sleep spindle database from 772 healthy children and shows age-specific patterns in spindle features across development.

The paper shows that the hippocampus is necessary for consolidating a task not initially requiring it, using motor sequence learning in hippocampal amnesics and controls.

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

The paper characterizes the spatial and temporal dynamics of slow oscillation-spindle coupling during sleep and finds individual variability in coupling phase that is stable across nights but not linked to memory change.

This study characterizes individual variability in slow and fast sleep spindle frequency and topography using EEG recordings and introduces a method to reliably separate spindle components across sleep stages.