Sakae Tanaka

This study examines how insulin resistance relates to hippocampal volume and cognitive performance in mild cognitive impairment and Alzheimer's disease.

The paper identifies a treatment-resistant fibroblast state in RA synovitis that drives chronic inflammation through senescence-associated mechanisms and highlights therapeutic targets beyond cytokine inhibition.

This study investigates diurnal variation in human SCN activity using perfusion imaging, finding higher activity at noon and lower in the early morning, aligning with rodent patterns under light conditions.

This study shows that nutrient availability regulates chondroprogenitor accumulation and differentiation in the growth plate, with IGF-1 promoting differentiation after nutrient recovery.

The paper introduces iSCseq, a method that captures subcellular transcriptomic changes in living cells, revealing new osteoclast subsets and subcellular connections.