An APOC1+ inflammatory CAF-like state drives a senescent, treatment-resistant niche in rheumatoid arthritis
Risa Yoshihara, Sotaro Nakajima, Reo Yamazato, Tomoya Yoshida, Ikuo Takazawa, Yasunori Omata, Teh-Wei Wang, Kazuyoshi Ishigaki, Takahiro Itamiya, Mineto Ota, Yoichi Yasunaga, Yuichiro Fujieda, Takumi Matsumoto, Hirofumi Shoda, Kazuhiko Yamamoto, , Keishi Fujio
The paper identifies a treatment-resistant fibroblast state in RA synovitis that drives chronic inflammation through senescence-associated mechanisms and highlights therapeutic targets beyond cytokine inhibition.
bioRxiv · Jun 29, 2026 · PreprintImmunology