Zvi Shalev

The paper introduces BigRNA, an RNA foundation model that predicts RNA biology from DNA sequence and identifies therapeutic effects of SBOs on gene expression and splicing.

This study evaluates off-target effects of steric-blocking oligonucleotides using RNA-seq and finds that in silico methods have limited utility for predicting these effects.

This paper shows that the ATP7B variant c.1934T>G causes exon 6 skipping, leading to loss of function and confirming its pathogenicity in Wilson Disease.