Yao‐Ting Huang

LongPhase-TO reconstructs somatic haplotypes from tumor-only long-read sequencing, improving variant calling accuracy and haplotype block size.

LongPhase-S improves somatic variant accuracy by jointly estimating tumor purity and recalibrating variants using somatic haplotyping in long-read sequencing.

This study identifies three combinatorial mutations associated with colistin resistance in mcr-negative Shewanella algae using comparative genomics.

This paper improves Oxford Nanopore sequencing accuracy by demodifying DNA and using Modpolish to correct modification errors without losing the epigenome.

LongPhase rapidly phases SNPs and SVs in human genomes using long reads, achieving chromosome-scale phasing in 10-20 minutes.

This paper introduces Homopolish, a method that improves Nanopore genome assembly quality using homologous sequences, achieving Q50-Q90 quality without Illumina data.