Chih‐Hsiang Chang

UniScore, a unified and universal measure for peptide identification by multiple search engines

UniScore integrates and standardizes outputs from multiple search engines in proteomics, outperforming single search engines in large-scale data analysis.

Water droplet-in-oil digestion method for single-cell proteomics

The paper introduces a water droplet-in-oil digestion method for single-cell proteomics that improves protein and peptide recovery and enables quantification of 462 proteins from 100 cells.

Correcting Modification-Mediated Errors in Nanopore Sequencing by Nucleotide Demodification and in silico Correction

This paper improves Oxford Nanopore sequencing accuracy by demodifying DNA and using Modpolish to correct modification errors without losing the epigenome.

Sequence-specific model for predicting peptide collision cross-section values in proteomic ion mobility spectrometry

The paper develops a sequence-specific model to predict peptide collision cross-section values using amino-acid sequence and charge state information from proteomic data.

Exploring the Landscape of Ectodomain Shedding by Quantitative Protein Terminomics

The paper identifies cleavage sites of ectodomain shedding in 10 human cell lines using mass spectrometry and finds 411 cleavage sites on 132 membrane proteins.